Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4

Alexander Lukasz; Jan Beneke; Kristina Thamm; Jan T. Kielstein; Jan Menne; Jan-Henrik Mikesch; Bernhard M. W. Schmidt; Hermann Haller; Philipp Kümpers; Sascha David; Mario Schiffer

doi:10.1155/2015/670248

Mediators of Inflammation (Jan 2015)

Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4

Alexander Lukasz,
Jan Beneke,
Kristina Thamm,
Jan T. Kielstein,
Jan Menne,
Jan-Henrik Mikesch,
Bernhard M. W. Schmidt,
Hermann Haller,
Philipp Kümpers,
Sascha David,
Mario Schiffer

Affiliations

Alexander Lukasz: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
Jan Beneke: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
Kristina Thamm: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
Jan T. Kielstein: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
Jan Menne: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
Jan-Henrik Mikesch: Department of Hematology, Hemostaseology, Oncology and Pneumonology, University Hospital Münster, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany
Bernhard M. W. Schmidt: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
Hermann Haller: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
Philipp Kümpers: Department of Medicine, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany
Sascha David: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
Mario Schiffer: Department of Nephrology & Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany

DOI: https://doi.org/10.1155/2015/670248
Journal volume & issue: Vol. 2015

Abstract

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Escherichia coli O104:H4-associated hemolytic uremic syndrome (HUS) is characterized by Shiga toxin-induced vascular damage. As indicated by recent studies, dysregulation of the angiopoietin (Angpt)/Tie2 ligand receptor system may be crucial for endothelial dysfunction in HUS. Early Angpt-2 levels quantified in 48 adult HUS patients were predictive for a complicated clinical course, in particular for need of hemodialysis and mechanical ventilation as well as occurrence of seizures. In vitro challenge of human umbilical vein endothelial cells with patients’ sera indicated an injurious mediator role of Angpt-2 opening future perspectives for mitigating endothelial activation in HUS.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://www.hindawi.com/journals/mi/

About the journal