Bone mineral density and trabecular bone tissue quality in obese men

Abstract

Obesity and osteoporosis are the two metabolic dise­ases with increased prevalence over last decades and a strong impact on the global morbidity and mortality have gained a status of major health threats worldwide. There is evidence that the higher body mass index (BMI) values are associated with greater bone mineral density (BMD) resulting in a site-specific protective effect for fragility fractures. On the other hand, higher BMI values increases incidence of falls and is associated with worse fractures consolidation. However, trabecular bone score (TBS) indirectly explores bone quali­ty, independently of BMD. The aim of the study was to determine the connection between the BMD and TBS parameters in Ukrainian men suffering from obesity. Methods. We examined 396 men aged 40–89 years, by the BMI all the subjects were divided into 2 groups: Group A — with obesity and BMI ≥ 30 kg/m2 (n = 129) and Group B — without obesity and BMI < 30 kg/m2 (n = 267). The BMD of total body, lumbar spine at the site L1–L4, femur and forearm were measured by DXA (Prodigy, GEHC Lunar, Madison, WI, USA). The TBS of L1–L4 was assessed by means of TBS iNsight (Med-Imaps, Pessac, France). Results. In general, obese men had a significantly higher BMD of lumbar spine, femoral neck, total body and ultradistal forearm (p < 0.001) in comparison with men without obesity. The TBS of L1–L4 was significantly lower in obese men compared to non-obese men (p < 0.001). The significant positive correlation between the fat mass and the BMD at different sites was observed. The correlation between the fat mass and TBS of L1–L4 was also significant, but negative. Conclusions. Obesity negatively affects the quality of trabecular bone, while bone mineral density was significantly higher.

Keywords

• trabecular bone score
• bone mineral density
• men
• obesity