Nature Communications (Nov 2017)

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

  • Chengzhang Fu,
  • Asfandyar Sikandar,
  • Jannik Donner,
  • Nestor Zaburannyi,
  • Jennifer Herrmann,
  • Michael Reck,
  • Irene Wagner-Döbler,
  • Jesko Koehnke,
  • Rolf Müller

DOI
https://doi.org/10.1038/s41467-017-01671-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell lines