Nature Communications (Nov 2017)
The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
Abstract
The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell lines