Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis

Jingyi Shan; Jingyi Shan; Suxian Liu; Suxian Liu; Haoyue Liu; Jianye Yuan; Jiang Lin

doi:10.3389/fphar.2023.1221849

Frontiers in Pharmacology (Aug 2023)

Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis

Jingyi Shan,
Jingyi Shan,
Suxian Liu,
Suxian Liu,
Haoyue Liu,
Jianye Yuan,
Jiang Lin

Affiliations

Jingyi Shan: Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jingyi Shan: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Suxian Liu: Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Suxian Liu: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Haoyue Liu: Department of Intensive Care Unit, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jianye Yuan: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jiang Lin: Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fphar.2023.1221849
Journal volume & issue: Vol. 14

Abstract

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Ulcerative colitis (UC) is a refractory inflammatory bowel disease, and the outcomes of conventional therapies of UC, including 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are not satisfied with patients and physicians with regard to adverse reactions and financial burden. The abnormality of the intestinal mucosal barrier in the pathogenesis of UC was verified. Qingchang Suppository (QCS) is an herbal preparation and is effective in treating ulcerative proctitis. The mechanism of QCS and its active ingredients have not been concluded especially in mucosal healing. This review elucidated the potential mechanism of QCS from the intestinal mucosal barrier perspective to help exploring future QCS research directions.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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