Association of ischemic placental disease in a Southern California Birth Cohort and PM2.5 chemical species and oxidative potential markers

Jonathan Liu; Qi Meng; Jiaqi Shen; Irish del Rosario; Pascale S J Lakey; Manabu Shiraiwa; Suzanne E Paulson; Scott Weichenthal; Yifang Zhu; Farzan Oroumiyeh; Carla Janzen; Sherin U Devaskar; Michael Jerrett; Beate Ritz

doi:10.1088/2752-5309/ad503b

Environmental Research: Health (Jan 2024)

Association of ischemic placental disease in a Southern California Birth Cohort and PM2.5 chemical species and oxidative potential markers

Jonathan Liu,
Qi Meng,
Jiaqi Shen,
Irish del Rosario,
Pascale S J Lakey,
Manabu Shiraiwa,
Suzanne E Paulson,
Scott Weichenthal,
Yifang Zhu,
Farzan Oroumiyeh,
Carla Janzen,
Sherin U Devaskar,
Michael Jerrett,
Beate Ritz

Affiliations

Jonathan Liu: ORCiD; Department of Environmental Health Sciences , University of California, Los Angeles Fielding School of Public Health, Los Angeles, CA 90095, United States of America
Qi Meng: ORCiD; Department of Epidemiology, University of California, Los Angeles Fielding School of Public Health , Los Angeles, CA 90095, United States of America
Jiaqi Shen: Department of Atmospheric and Oceanic Sciences, University of California, Los Angeles , Los Angeles, CA 90095, United States of America
Irish del Rosario: Department of Epidemiology, University of California, Los Angeles Fielding School of Public Health , Los Angeles, CA 90095, United States of America
Pascale S J Lakey: Department of Chemistry, University of California, Irvine , Irvine, CA 92697, United States of America
Manabu Shiraiwa: Department of Chemistry, University of California, Irvine , Irvine, CA 92697, United States of America
Suzanne E Paulson: ORCiD; Department of Atmospheric and Oceanic Sciences, University of California, Los Angeles , Los Angeles, CA 90095, United States of America
Scott Weichenthal: Department of Epidemiology, Biostatistics, and Occupational Health, McGill University , Montreal, Quebec H3A 1A2, Canada
Yifang Zhu: Department of Environmental Health Sciences , University of California, Los Angeles Fielding School of Public Health, Los Angeles, CA 90095, United States of America
Farzan Oroumiyeh: Department of Environmental Health Sciences , University of California, Los Angeles Fielding School of Public Health, Los Angeles, CA 90095, United States of America
Carla Janzen: Department of Obstetrics and Gynecology, University of California, Los Angeles David Geffen School of Medicine , Los Angeles, CA 90095, United States of America
Sherin U Devaskar: Department of Pediatrics, University of California , Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, United States of America
Michael Jerrett: Department of Environmental Health Sciences , University of California, Los Angeles Fielding School of Public Health, Los Angeles, CA 90095, United States of America
Beate Ritz: ORCiD; Department of Epidemiology, University of California, Los Angeles Fielding School of Public Health , Los Angeles, CA 90095, United States of America

DOI: https://doi.org/10.1088/2752-5309/ad503b
Journal volume & issue: Vol. 2, no. 3
p. 031002

Abstract

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Road traffic is a significant source of particulate matter pollution, whose exposure is a significant risk factor in pregnancy-related health outcomes. The exact mechanisms behind the relationship between traffic-related air pollution (TRAP) exposure and adverse pregnancy outcomes remain unclear. We aim to assess the relationship between exposure to brake and tire wear-associated metals and oxidative potential and ischemic placental disease (IPD). Data were assembled from a final population of 178 women who sought specialized prenatal care at UCLA between 2016 and 2019 in Los Angeles, CA. Modeled first trimester exposures to chemical constituents and oxidative stress potential of PM _2.5 , black carbon, and PM _2.5 mass concentration. Speciated measurements included tracers of brake wear (barium), tire wear (zinc), and oxidative potential markers based on metal concentrations (KM-SUB-ELF ROS) or laboratory assays (DTT loss, OH radical formation). Exposures were modeled by integrating data from filter samples, a low-cost PM _2.5 sensor network, and land-use data. We used logistic regression to estimate the associations between air pollution exposures and IPD, adjusting for covariates assessed through medical records and interviews. Scaled to the interquartile range, odds ratios (95% CI) were as follows: barium OR: 1.7 (1.1, 2.7), zinc OR: 1.4 (.86, 2.4), and oxidative potential markers, both modeled as well as measured through DTT loss and OH formation assays (ORs ranging from 1.1-2.0). Point estimates of effect sizes for PM _2.5 and black carbon were lower than most measurements (ORs: 1.3-1.4). mass and black carbon. Our findings suggest two key points: (i) metals associated with brake and tire wear, currently unregulated, may play a role in the relationship between TRAP and adverse pregnancy outcomes, and (ii) reducing tailpipe emissions may not be sufficient to protect pregnant women from TRAP.

Published in Environmental Research: Health

ISSN: 2752-5309 (Online)
Publisher: IOP Publishing
Country of publisher: United Kingdom
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences; Medicine: Public aspects of medicine
Website: https://iopscience.iop.org/journal/2752-5309

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