Digital Biomarkers (Mar 2024)
Fatigue-Related Changes of Daily Function: Most Promising Measures for the Digital Age
- Walter Maetzler,
- Leonor Correia Guedes,
- Kirsten Nele Emmert,
- Jennifer Kudelka,
- Hanna Luise Hildesheim,
- Emma Paulides,
- Hayley Connolly,
- Kristen Davies,
- Valentina Dilda,
- Teemu Ahmaniemi,
- Luisa Avedano,
- Raquel Bouça-Machado,
- Michael Chambers,
- Meenakshi Chatterjee,
- Peter Gallagher,
- Johanna Graeber,
- Corina Maetzler,
- Hanna Kaduszkiewicz,
- Norelee Kennedy,
- Victoria Macrae,
- Laura Carrasco Marín,
- Anusha Moses,
- Alessandro Padovani,
- Andrea Pilotto,
- Natasha Ratcliffe,
- Ralf Reilmann,
- Madalena Rosario,
- Stefan Schreiber,
- Dina De Sousa,
- Geert Van Gassen,
- Lori Ann Warring,
- Klaus Seppi,
- C. Janneke van der Woude,
- Joaquim J. Ferreira,
- Wan-Fai Ng
Affiliations
- Walter Maetzler
- Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany
- Leonor Correia Guedes
- Instituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
- Kirsten Nele Emmert
- Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany
- Jennifer Kudelka
- Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany
- Hanna Luise Hildesheim
- Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany
- Emma Paulides
- Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands
- Hayley Connolly
- School of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland
- Kristen Davies
- Translational and Clinical Research Institute, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK
- Valentina Dilda
- CHDI Management, CHDI Foundation, Princeton, NJ, USA
- Teemu Ahmaniemi
- Teknologian tutkimuskeskus VTT Oy, Espoo, Finland
- Luisa Avedano
- European Federation of Crohn’s and Ulcerative Colitis, Brussels, Belgium
- Raquel Bouça-Machado
- Instituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
- Michael Chambers
- MC Healthcare Evaluation, London, UK
- Meenakshi Chatterjee
- Janssen Research and Development, Cambridge, MA, USA
- Peter Gallagher
- Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
- Johanna Graeber
- Institute of General Medicine, University Medical Centre Schleswig-Holstein, Kiel University, Kiel, Germany
- Corina Maetzler
- Department of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany
- Hanna Kaduszkiewicz
- Institute of General Medicine, University Medical Centre Schleswig-Holstein, Kiel University, Kiel, Germany
- Norelee Kennedy
- School of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland
- Victoria Macrae
- Translational and Clinical Research Institute, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK
- Laura Carrasco Marín
- Asociación Parkinson Madrid, Madrid, Spain
- Anusha Moses
- School of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland
- Alessandro Padovani
- Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
- Andrea Pilotto
- Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
- Natasha Ratcliffe
- Parkinson’s UK, London, UK
- Ralf Reilmann
- George-Huntington-Institute, R&D-Campus/Technology-Park Münster, Münster, Germany
- Madalena Rosario
- Instituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
- Stefan Schreiber
- Department of Internal Medicine I, University Medical Centre Schleswig-Holstein, Kiel University, Kiel, Germany
- Dina De Sousa
- European Huntington’s Association, Moerbeke, Belgium
- Geert Van Gassen
- Medical Department, Takeda, Brussels, Belgium
- Lori Ann Warring
- Janssen LLC, GCSO Immunology, Horsham, PA, USA
- Klaus Seppi
- Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
- C. Janneke van der Woude
- Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands
- Joaquim J. Ferreira
- Instituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
- Wan-Fai Ng
- Translational and Clinical Research Institute, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK
- DOI
- https://doi.org/10.1159/000536568
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 30 – 39
Abstract
Background: Fatigue is a prominent symptom in many diseases and is strongly associated with impaired daily function. The measurement of daily function is currently almost always done with questionnaires, which are subjective and imprecise. With the recent advances of digital wearable technologies, novel approaches to evaluate daily function quantitatively and objectively in real-life conditions are increasingly possible. This also creates new possibilities to measure fatigue-related changes of daily function using such technologies. Summary: This review examines which digitally assessable parameters in immune-mediated inflammatory and neurodegenerative diseases may have the greatest potential to reflect fatigue-related changes of daily function. Key Messages: Results of a standardized analysis of the literature reporting about perception-, capacity-, and performance-evaluating assessment tools indicate that changes of the following parameters: physical activity, independence of daily living, social participation, working life, mental status, cognitive and aerobic capacity, and supervised and unsupervised mobility performance have the highest potential to reflect fatigue-related changes of daily function. These parameters thus hold the greatest potential for quantitatively measuring fatigue in representative diseases in real-life conditions, e.g., with digital wearable technologies. Furthermore, to the best of our knowledge, this is a new approach to analysing evidence for the design of performance-based digital assessment protocols in human research, which may stimulate further systematic research in this area.
Keywords
- activities of daily life
- international classification of functioning, disability and health
- performance
- wearables
