Animals (Oct 2022)

Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs

  • Jie Zheng,
  • Yehui Duan,
  • Changbing Zheng,
  • Jiayi Yu,
  • Fengna Li,
  • Qiuping Guo,
  • Yulong Yin

DOI
https://doi.org/10.3390/ani12212944
Journal volume & issue
Vol. 12, no. 21
p. 2944

Abstract

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Obesity is a matter of concern to the public. Abundant evidence has been accumulated that nutritional intervention is a promising strategy to address this health issue. The objective of this study is to investigate alterations in the lipid metabolism in white adipose tissues and the gut microbiota of Shaziling pigs challenged by long-term protein restriction. Results showed that compared with the control group, reducing the protein level by 20% (−20%) increased the mRNA abundance of FABP4 in white adipose tissues (p p p Lachnospiraceae XPB1014 group abundance at the genus level (p < 0.01). Collectively, these results indicated that a 20% protein reduction could modulate lipid metabolism and alter the colonic microbiota of Shaziling pigs, an approach which might be translated into a treatment for obesity.

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