Communications Biology (Jan 2022)

Inferring the stabilization effects of SARS-CoV-2 variants on the binding with ACE2 receptor

  • Mattia Miotto,
  • Lorenzo Di Rienzo,
  • Giorgio Gosti,
  • Leonardo Bo’,
  • Giacomo Parisi,
  • Roberta Piacentini,
  • Alberto Boffi,
  • Giancarlo Ruocco,
  • Edoardo Milanetti

DOI
https://doi.org/10.1038/s42003-021-02946-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 13

Abstract

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Miotto et al. perform molecular dynamics simulations on a selected set of possible SARS-CoV-2 spike variants in order to assess the stabilizing effect of particular amino acid substitutions on the molecular complex. Their analysis can help to monitor further possible spike variants.