Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus

Kyeonghye Guk; Hyeran Kim; Miyeon Lee; Yoon-Aa Choi; Seul Gee Hwang; Gaon Han; Hye-Nan Kim; Hongki Kim; Hwangseo Park; Dongeun Yong; Taejoon Kang; Eun-Kyung Lim; Juyeon Jung

doi:10.1038/s41467-020-17246-w

Nature Communications (Jul 2020)

Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus

Kyeonghye Guk,
Hyeran Kim,
Miyeon Lee,
Yoon-Aa Choi,
Seul Gee Hwang,
Gaon Han,
Hye-Nan Kim,
Hongki Kim,
Hwangseo Park,
Dongeun Yong,
Taejoon Kang,
Eun-Kyung Lim,
Juyeon Jung

Affiliations

Kyeonghye Guk: Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
Hyeran Kim: Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
Miyeon Lee: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST)
Yoon-Aa Choi: BioNano Health Guard Research Center, KRIBB
Seul Gee Hwang: Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
Gaon Han: Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
Hye-Nan Kim: Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
Hongki Kim: Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
Hwangseo Park: Department of Bioscience and Biotechnology, Sejong University
Dongeun Yong: Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine
Taejoon Kang: Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
Eun-Kyung Lim: Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
Juyeon Jung: Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)

DOI: https://doi.org/10.1038/s41467-020-17246-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Rapid detection of antiviral resistant strains is important for effective clinical treatment. Here the authors develop an antibody which specifically binds to multidrug-resistant influenza virus and demonstrated detection in a number of different systems using the antibody.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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