Vitamin D status in idiopathic Parkinson’s disease: an Egyptian study

Abstract

Abstract Background Vitamin D is suggested to play an important role in neurodegenerative disorders. Objective To examine the association between serum 25 vitamin D3 and Parkinson’s disease (PD). Materials and methods Fifty patients suffering from PD and fifty age- and sex-matched healthy control subjects were included in the study. Patients were subjected to complete clinical assessment, and Unified Parkinson Disease Rating Scale (UPDRS) was done to evaluate severity of PD. Measurement of serum 25 vitamin D3 using enzyme-linked immuno sorbent assay (ELISA) was done for both patients and controls. Results Serum 25 vitamin D3 was significantly lower in PD patients compared to healthy controls. Twenty-five vitamin D3 serum level was significantly negatively correlated with age and age at onset of disease but not significantly correlated with disease duration and severity of Parkinson’s disease. Multiple regression analysis showed that serum 25 vitamin D3 was not found to be predictor for severity of PD. Conclusion There is an association between low vitamin D levels and PD. Therefore, vitamin D may have a role in the pathophysiology of PD.

Keywords

• Serum 25 vitamin D3
• Parkinson’s disease (PD)