Nature Communications (Feb 2017)

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

  • Cheng Xue Qin,
  • Lauren T. May,
  • Renming Li,
  • Nga Cao,
  • Sarah Rosli,
  • Minh Deo,
  • Amy E. Alexander,
  • Duncan Horlock,
  • Jane E. Bourke,
  • Yuan H. Yang,
  • Alastair G. Stewart,
  • David M. Kaye,
  • Xiao-Jun Du,
  • Patrick M. Sexton,
  • Arthur Christopoulos,
  • Xiao-Ming Gao,
  • Rebecca H. Ritchie

DOI
https://doi.org/10.1038/ncomms14232
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detrimental FPR signalling, showing beneficial therapeutic effect in a mouse model of cardiac infarction.