Frontiers in Endocrinology (May 2022)

Higher Serum Soluble TREM2 as a Potential Indicative Biomarker for Cognitive Impairment in Inadequately Controlled Type 2 Diabetes Without Obesity: The DOR-KyotoJ-1

  • Masashi Tanaka,
  • Masashi Tanaka,
  • Hajime Yamakage,
  • Kazuya Muranaka,
  • Tsutomu Yamada,
  • Rika Araki,
  • Atsushi Ogo,
  • Yuka Matoba,
  • Tetsuhiro Watanabe,
  • Miho Saito,
  • Seiichiro Kurita,
  • Kazuya Yonezawa,
  • Tsuyoshi Tanaka,
  • Masahiro Suzuki,
  • Morio Sawamura,
  • Morio Matsumoto,
  • Motonobu Nishimura,
  • Toru Kusakabe,
  • Hiromichi Wada,
  • Koji Hasegawa,
  • Kazuhiko Kotani,
  • Mitsuhiko Noda,
  • Mitsuhiko Noda,
  • Noriko Satoh-Asahara,
  • Noriko Satoh-Asahara

DOI
https://doi.org/10.3389/fendo.2022.880148
Journal volume & issue
Vol. 13

Abstract

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ObjectiveType 2 diabetes is a risk factor for dementia. We investigated whether serum levels of soluble triggering receptor expressed on myeloid cell 2 (sTREM2), a soluble form of the cell surface receptor TREM2, were predictive of cognitive impairment in type 2 diabetes without obesity.MethodsA total of 166 Japanese patients with type 2 diabetes without obesity were followed-up for 2 years. We measured clinical parameters, assessed cognitive function using the mini-mental state examination (MMSE), quantified and divided serum sTREM2 levels into quartiles, and examined the longitudinal associations.ResultsDuring the follow-up, HbA1c levels were elevated in 98 patients and decreased in 68 patients. In the HbA1c-elevated group, higher sTREM2 levels at baseline showed a significant association with a greater tendency for reduction in MMSE scores (P for trend = 0.015), whereas they were not significantly associated with other examined parameters. In the HbA1c-decreased group, there was no significant association between sTREM2 levels at baseline and changes in MMSE scores, but higher sTREM2 levels at baseline were significantly associated with a greater tendency for reduction in waist circumference (P for trend = 0.027), homeostasis model assessment of insulin resistance (P for trend = 0.039), and sTREM2 levels (P for trend = 0.023).ConclusionsGlycemic control is suggested to be important in preventing cognitive impairment in patients with type 2 diabetes without obesity. Higher serum sTREM2 levels would be a predictive marker for cognitive impairment in inadequately controlled type 2 diabetes without obesity.

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