Comparative results of use and switching of anti-TNF-alpha agents in adult Behçet’s uveitis

Abstract

Purpose: This study was planned to compare the clinical results and optical coherence tomography (OCT) data of patients who underwent adalimumab (ADA), infliximab (IFX) and switched protocols between these two methods in cases of Behçet’s associated uveitis (BAU). Methods: The patients with BAU who were treated with anti-TNF-α agents for at least one year were qualified for the chart review. The outcome parameters were the steroid-free remission state, the best-corrected visual acuity (BCVA), the central macular thickness (CMT), and the subfoveal choroidal thickness (SFCT) of the patients at the last visit. Results: After a mean follow-up of 16.60 months, the rate of active inflammation decreased from 63.6% to 15.1%. Mean BCVA increased, mean CMT and mean SFCT decreased significantly at the last visit (P < 0.001, P < 0.001, respectively). Conclusion: Anti-TNF-α treatment and switching protocols between these two agents effectively and safely control intraocular inflammation in BAU patients.

Keywords

• anti-tnf-alpha
• behçet’s disease
• biologic agent
• choroidal thickness
• intraocular inflammation
• switched