Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd (Aug 2017)
Effect of Hydroalchoholic Extract Sumac (Rhus coriaria L.) on Expression of Passive Avoidance Learning in Gonadectomized Male Rats
Abstract
Introduction: Learning and memory is characteristically human to survive; reducing sexual hormones in aging and the side effects of chemical drugs are factors that can cause memory and learning disruption. In this study the effect of hydroalchoholic extract sumac (Rhus coriaria L.) on expression passive avoidance learning in gonadectomized male rats was studied. Methods: In this experimental study, 32 adult Wistar rats with a weight of 230±20 were put in four groups (8 rats per group), including: received healthy solvent extract Dimethyl sulfoxide (DMSO), gonadectomized received of DMSO and doses of 25 and 50 mg/ kg extract sumac . Firstly, , rats injected intraperitoneally with ketamine (75 mg/kg) and xylazine (10 mg/kg) anesthesia, gonads removed after 15 days recovery period, extensive testing. Passive avoidance test by the Shuttle box device after treatment by the same conditions was performed for all groups. All treatment was performed intraperitoneally and a half hours before the test on the second day (check expression).The data were analyzed by the one-way ANOVA and Tukey test (P<0.05). Results: Results showed that in the gonadectomized group received solvent extract (DMSO) (3/0 cc) a significant reduced was found in latency to enter the dark room compared to DMSO control groups (P <0.001). The groups The groups receiving the extract sumac(Rhus coriaria L.) at a doses of 50 and 25 mg / kg showed a significant increase in latency in the dark room compared with the group receiving the gonadectomy receiving DMSO(P<0.05). Conclusion: Results show that the gonadectomy reduces the incidence of avoidance learning and In gonadectomized rats, hydroalcoholic extract of sumac increases the incidence of passive avoidance learning.
