The Content of Insulin-Like Growth Factor 1 and Essential Trace Elements in the Blood Plasma of Children with Different Forms of Short Stature

Abstract

The content of insulin-like growth factor 1 and essential trace elements (zinc, selenium, copper, manganese, chromium) was studied in the blood plasma of children with short stature, depending on the etiology of the disease. The presence of a significant imbalance of essential trace elements in patients with short stature, primarily caused by deficiency of growth hormone and insulin-like growth factor 1, was established. The significant weak correlation between indicators of insulin-like growth factor 1 and the average level of zinc in the blood plasma of children with short stature was noted in the whole group. At the same time, the significant strong correlation between indicators of insulin-like growth factor‑1 and zinc in the blood plasma was revealed in children with isolated growth hormone deficiency, full or partial. No correlation was found between indices of insulin-like growth factor 1 in the blood plasma and indices of selenium, manganese, chromium, copper.

Keywords

• essential trace elements
• insulin-like growth factor 1
• children
• short stature
• growth hormone deficiency.