Synthetic lethality between TP53 and ENDOD1

Zizhi Tang; Ming Zeng; Xiaojun Wang; Chang Guo; Peng Yue; Xiaohu Zhang; Huiqiang Lou; Jun Chen; Dezhi Mu; Daochun Kong; Antony M. Carr; Cong Liu

doi:10.1038/s41467-022-30311-w

Nature Communications (May 2022)

Synthetic lethality between TP53 and ENDOD1

Zizhi Tang,
Ming Zeng,
Xiaojun Wang,
Chang Guo,
Peng Yue,
Xiaohu Zhang,
Huiqiang Lou,
Jun Chen,
Dezhi Mu,
Daochun Kong,
Antony M. Carr,
Cong Liu

Affiliations

Zizhi Tang: Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University
Ming Zeng: Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University
Xiaojun Wang: Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University
Chang Guo: Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University
Peng Yue: Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University
Xiaohu Zhang: Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University
Huiqiang Lou: School of Life Sciences, China Agricultural University
Jun Chen: College of Life Sciences, Zhejiang University
Dezhi Mu: Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University
Daochun Kong: School of Life Sciences, Peking University
Antony M. Carr: Genome Damage and Stability Centre, School of Life Science, University of Sussex
Cong Liu: Department of Paediatrics, SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University

DOI: https://doi.org/10.1038/s41467-022-30311-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

The authors uncover synthetic lethality between TP53 and ENDOD1, which contains an atypical endonuclease domain. Co-depleted G1 cells accumulate single stranded DNA and die. Combined with xenograft data the work identifies ENDOD1 as a potential cancer-specific SL drug discovery target.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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