Synergy Effect of Combined Near and Mid-Infrared Fibre Spectroscopy for Diagnostics of Abdominal Cancer
Thaddäus Hocotz,
Olga Bibikova,
Valeria Belikova,
Andrey Bogomolov,
Iskander Usenov,
Lukasz Pieszczek,
Tatiana Sakharova,
Olaf Minet,
Elena Feliksberger,
Viacheslav Artyushenko,
Beate Rau,
Urszula Zabarylo
Affiliations
Thaddäus Hocotz
Department of Surgery, Charité University of Berlin, 13353 Berlin, Germany
Olga Bibikova
Art Photonics GmbH, Rudower Chaussee 46, 12489 Berlin, Germany
Valeria Belikova
Laboratory of Multivariate Analysis and Global Modelling, Samara State Technical University, Molodogvardeyskaya 244, 443100 Samara, Russia
Andrey Bogomolov
Laboratory of Multivariate Analysis and Global Modelling, Samara State Technical University, Molodogvardeyskaya 244, 443100 Samara, Russia
Iskander Usenov
Art Photonics GmbH, Rudower Chaussee 46, 12489 Berlin, Germany
Lukasz Pieszczek
Institute of Chemistry, University of Silesia in Katowice, 9 Szkolna Street, 40006 Katowice, Poland
Tatiana Sakharova
Art Photonics GmbH, Rudower Chaussee 46, 12489 Berlin, Germany
Olaf Minet
CC06-CharitéCentrum 6, Center for Diagnostic and Interventional Radiology and Nuclear Medicine, Charité Universitätsmedizin Berlin, CBF Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
Elena Feliksberger
Art Photonics GmbH, Rudower Chaussee 46, 12489 Berlin, Germany
Viacheslav Artyushenko
Art Photonics GmbH, Rudower Chaussee 46, 12489 Berlin, Germany
Beate Rau
Department of Surgery, Charité University of Berlin, 13353 Berlin, Germany
Urszula Zabarylo
BIH Berlin Institute of Health, BCRT-Center for Regenerative Therapies, Cranach Haus, Charité - Universitätsmedizin Berlin, CVK Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
Cancers of the abdominal cavity comprise one of the most prevalent forms of cancers, with the highest contribution from colon and rectal cancers (12% of the human population), followed by stomach cancers (4%). Surgery, as the preferred choice of treatment, includes the selection of adequate resection margins to avoid local recurrences due to minimal residual disease. The presence of functionally vital structures can complicate the choice of resection margins. Spectral analysis of tissue samples in combination with chemometric models constitutes a promising approach for more efficient and precise tumour margin identification. Additionally, this technique provides a real-time tumour identification approach not only for intraoperative application but also during endoscopic diagnosis of tumours in hollow organs. The combination of near-infrared and mid-infrared spectroscopy has advantages compared to individual methods for the clinical implementation of this technique as a diagnostic tool.
