Immunodiagnostics of tuberculosis: 10-year experience of using immunological tests in Russia

Abstract

The introduction of a new generation of immunological tests based on in vitro or in vivo reactions using specific ЕSAT-6 and CFP-10 peptides allowed changing the understanding of the diagnosis of latent tuberculosis infection, as well as improving the diagnosis of tuberculosis in pediatric and adult practice. The article presents the analysis of the Russian studies conducted over the past ten years aimed to investigate the informativeness of a skin test with tuberculosis recombinant allergen. High diagnostic significance of the skin test, comparable to the internationally recognized IGRA-tests has been proved. Today, the test with TRA in the form of locally manufactured Diaskintest has been introduced inRussianot only to the practice of TB units, but also in the practice of pediatricians, pulmonologists and infectious disease specialists.

Keywords

• иммунодиагностика
• диагностика туберкулеза
• латентная туберкулезная инфекция
• пробы с диаскинтестом
• igra-тесты
• quantiferon-tb
• elispot