OncoTargets and Therapy (Mar 2020)
Combination Strategies of Checkpoint Immunotherapy in Metastatic Breast Cancer
Abstract
Zhi Bing Liu,1 Luyan Zhang,2 Jia Bian,3 Jinbo Jian1 1Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong Province 256600, People’s Republic of China; 2Department of Oncology, Binzhou People’s Hospital, Binzhou, Shandong Province 256600, People’s Republic of China; 3Department of Radiology, Binzhou Medical University Hospital, Binzhou, Shandong Province 256600, People’s Republic of ChinaCorrespondence: Jinbo JianDepartment of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong Province 256600, People’s Republic of ChinaEmail [email protected]: Checkpoint immunotherapy is emerging as a new therapeutic approach for metastatic breast cancer. Monotherapy of immunoagents against PD1/PD-L1 or CTLA-4 has shown little efficacy in these patients. Recently, to determine the optimal use of immunotherapy, there has been a rapid expansion in the number of clinical trials developing immunotherapy combinations. These combination therapeutic approaches can enhance various aspects of cancer immunity, such as tumor antigenicity or intratumor T cell infiltration, which provides a theoretical basis for combining them with checkpoint immunotherapy to achieve synergistic effects. Here, we review the available data and ongoing efforts to establish the safety and efficacy of immunoagents in combination with chemotherapy, radiotherapy, HER2-targeted therapy, CDK4/6 inhibitors, PARP inhibitors, and another checkpoint immunoagents.Keywords: immunotherapy, breast, cancer, combination
