Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in trans-Acyltransferase Polyketide Synthases

• Christopher D. Fage,
• Munro Passmore,
• Ben P. Tatman,
• Helen G. Smith,
• Xinyun Jian,
• Upeksha C. Dissanayake,
• Mia E. Foran,
• G. Andrés Cisneros,
• Gregory L. Challis,
• Józef R. Lewandowski,
• Matthew Jenner

Affiliations

Christopher D. Fage

Department of Chemistry, University of Warwick, Coventry, U.K.

Munro Passmore

Department of Chemistry, University of Warwick, Coventry, U.K.

Ben P. Tatman

Department of Chemistry, University of Warwick, Coventry, U.K.

Helen G. Smith

Department of Chemistry, University of Warwick, Coventry, U.K.

Xinyun Jian

Department of Chemistry, University of Warwick, Coventry, U.K.

Upeksha C. Dissanayake

Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas, United States

Mia E. Foran

Department of Chemistry, University of Warwick, Coventry, U.K.

G. Andrés Cisneros

Department of Physics, University of Texas at ​Dallas, Richardson, Texas, United States

Gregory L. Challis

Department of Chemistry, University of Warwick, Coventry, U.K.

Józef R. Lewandowski

Department of Chemistry, University of Warwick, Coventry, U.K.

Matthew Jenner

Department of Chemistry, University of Warwick, Coventry, U.K.