Nature Communications (Dec 2022)

Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas

  • Haifeng Zhang,
  • Busu Li,
  • Qunhua Huang,
  • Francesc López-Giráldez,
  • Yoshiaki Tanaka,
  • Qun Lin,
  • Sameet Mehta,
  • Guilin Wang,
  • Morven Graham,
  • Xinran Liu,
  • In-Hyun Park,
  • Anne Eichmann,
  • Wang Min,
  • Jenny Huanjiao Zhou

DOI
https://doi.org/10.1038/s41467-022-35262-w
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 21

Abstract

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The role of mitochondrial activity in angiogenesis is not entirely understood. Here, the authors show that mitochondria as a signaling hub and their dysfunction causes augmented TGFβ signaling to induce retinal sprouting retardation and vascular malformations.