Nature Communications (Dec 2017)

IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning

  • Nicolas Taulet,
  • Benjamin Vitre,
  • Christelle Anguille,
  • Audrey Douanier,
  • Murielle Rocancourt,
  • Michael Taschner,
  • Esben Lorentzen,
  • Arnaud Echard,
  • Benedicte Delaval

DOI
https://doi.org/10.1038/s41467-017-01479-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent cleavage furrow ingression and lumen positioning.