SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA

Abstract

In biological fluids of trauma patients the essential changes in soluble forms of immune system cells membrane antigens in different states have been revealed. The soluble forms of membrane antigens, which can makes up oligomers, consists of subunits, belong to one antigen, or which can make up soluble complexes (associations), composed of pair receptor–ligand. The changes in concentration of soluble analogs of membrane antigens in patients with mechanical injury, craniocerebral trauma and burning injury are the perspective prognostic markers of possibility of development complication. The state of soluble differentiation molecules pool is one from factors which define the outcomes of underlying disease. Peculiarity of immune system cells transcriptome, associated with mRNA of soluble and membrane differentiation antigens have prognostic character in trauma patients.

Keywords

• mechanical injury
• craniocerebral trauma
• burning injury
• soluble differentiation antigens
• molecules of histocompatibility
• immune response regulation