Infection and Drug Resistance (Aug 2022)

Rhizomucor pusillus Infection in a Patient with Acute Myeloid Leukaemia After Haematopoietic Stem Cell Transplantation: Clinical Impact of Metagenomics Next-Generation Sequencing

  • Liu L,
  • Wu H,
  • Liang J,
  • Wu W,
  • Peng Y,
  • Zhou H,
  • Li X

Journal volume & issue
Vol. Volume 15
pp. 4285 – 4290

Abstract

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Lilin Liu,1,* Huiqin Wu,2,* Jianghong Liang,3,* Wenhao Wu,3 Ye Peng,4 Hua Zhou,5 Xi Li3 1Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, People’s Republic of China; 2Department of Clinical Laboratory, The Third Hospital of Quzhou, Quzhou, Zhejiang, 321000, People’s Republic of China; 3Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People’s Hospital, Affifiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, People’s Republic of China; 4Hematology Department, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, 310014, People’s Republic of China; 5Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ye Peng, Tel +86-571-8589-3497, Fax +86-571-8589-3497, Email [email protected] Xi Li, Tel +86-571-8589-3800, Fax +86-571-8589-3800, Email [email protected]: Long-term chemotherapy and immunosuppressants in acute myeloid leukaemia (AML) patients can result in a high risk of opportunistic infections. Rhizomucor pusillus is an opportunistic pathogen that exists in nature, but infection caused by R. pusillus is rare in the clinic. Notably, the sensitivity and detection time of conventional diagnostic tools for this fungus usually falls short of the needs of clinical diagnosis, resulting in treatment failure. Currently, metagenomics next-generation sequencing (mNGS) has played an important role in the detection of pathogens. Here, we report a case of R. pusillus pneumonia in a haematopoietic stem cell transplantation (HSCT) patient, detected by the mNGS method.Keywords: Rhizomucor pusillus, acute myeloid leukaemia, metagenomics next-generation sequencing, fungus

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