Effects of Anti Epileptic Drugs; Phenytoin and Phenobarbital on Ossification Indices of Mouse Femur And Tibia And The Anti Teratogenic Effects of Folic Acid on the Reduction of Their Effects

Abstract

Introduction: Patients suffering from epilepsy have to take antiepileptic drugs forever. It has been suggested that epilepsy itself and antiepileptic drugs are teratogenic. All aspects of the abnormalities that are induced by these drugs are unclear. Therefore, the objectives of this study were to determine the effects of two routine antiepileptic drugs on ossification. Besides, there was an attempt to decrease their teratogenic effects by using folic acid. Materials and Methods: 81 female mice (BALB/c) were selected and divided into six groups. Pregnant mice were fed with phenytoin (45mg/kg), Phenobarbital (30mg/kg), phenytoin and folic acid (15

Keywords

• Epilepsy
• Phenobarbital
• Phenytoin
• Folic Acid