Hypertension in Pregnancy (Oct 2019)

Negative association between serum adropin and hypertensive disorders complicating pregnancy

  • Dong Lin,
  • Jian Yong,
  • Shuhua Ni,
  • Weichao Ou,
  • Xuerui Tan

DOI
https://doi.org/10.1080/10641955.2019.1657887
Journal volume & issue
Vol. 38, no. 4
pp. 237 – 244

Abstract

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Objective: Study the association of adropin and hypertensive disorders complicating pregnancy (HDCP). Methods: Patients with HDCP were matched with normotensive women (47 pairs). Adropin concentrations were detected by enzyme-linked immunosorbent assay. Results: Compared with the controls, the serum adropin levels were lower in the HDCP group (P < 0.001) and in HDCP subgroups (gestational hypertension, mild preeclampisa, and severe preeclampsia, term, preterm, early onset, and late onset) (all P < 0.05). After adjustment for confounders, adropin remained negatively associated with HDCP (P = 0.027). Conclusion: Lower adropin concentration is significantly associated with HDCP, suggesting that higher or normal adropin levels may be protective against HDCP.

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