Nature Communications (Dec 2018)
Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma
- Gary L. Gallia,
- Ming Zhang,
- Yi Ning,
- Michael C. Haffner,
- Denise Batista,
- Zev A. Binder,
- Justin A. Bishop,
- Christine L. Hann,
- Ralph H. Hruban,
- Masaru Ishii,
- Alison P. Klein,
- Douglas D. Reh,
- Lisa M. Rooper,
- Vafi Salmasi,
- Rafael J. Tamargo,
- Qing Wang,
- Tara Williamson,
- Tianna Zhao,
- Ying Zou,
- Alan K. Meeker,
- Nishant Agrawal,
- Bert Vogelstein,
- Kenneth W. Kinzler,
- Nickolas Papadopoulos,
- Chetan Bettegowda
Affiliations
- Gary L. Gallia
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- Ming Zhang
- Ludwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Yi Ning
- Department of Pathology, Johns Hopkins University School of Medicine
- Michael C. Haffner
- Department of Pathology, Johns Hopkins University School of Medicine
- Denise Batista
- Department of Pathology, Johns Hopkins University School of Medicine
- Zev A. Binder
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- Justin A. Bishop
- Department of Pathology, Johns Hopkins University School of Medicine
- Christine L. Hann
- Department of Oncology, Johns Hopkins University School of Medicine
- Ralph H. Hruban
- Department of Pathology, Johns Hopkins University School of Medicine
- Masaru Ishii
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- Alison P. Klein
- Department of Oncology, Johns Hopkins University School of Medicine
- Douglas D. Reh
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- Lisa M. Rooper
- Department of Pathology, Johns Hopkins University School of Medicine
- Vafi Salmasi
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- Rafael J. Tamargo
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- Qing Wang
- Ludwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Tara Williamson
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- Tianna Zhao
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- Ying Zou
- Department of Pathology, University of Maryland School of Medicine
- Alan K. Meeker
- Department of Pathology, Johns Hopkins University School of Medicine
- Nishant Agrawal
- Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins University School of Medicine
- Bert Vogelstein
- Ludwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Kenneth W. Kinzler
- Ludwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Nickolas Papadopoulos
- Ludwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Chetan Bettegowda
- Department of Neurosurgery, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07578-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 6
Abstract
Olfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined.
