Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA

C. E. Koch; K. Begemann; J. T. Kiehn; L. Griewahn; J. Mauer; M. E. Hess; A. Moser; S. M. Schmid; J. C. Brüning; H. Oster

doi:10.1038/s41467-020-16882-6

Nature Communications (Jun 2020)

Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA

C. E. Koch,
K. Begemann,
J. T. Kiehn,
L. Griewahn,
J. Mauer,
M. E. Hess,
A. Moser,
S. M. Schmid,
J. C. Brüning,
H. Oster

Affiliations

C. E. Koch: Institute of Neurobiology, University of Lübeck, CBBM
K. Begemann: Institute of Neurobiology, University of Lübeck, CBBM
J. T. Kiehn: Institute of Neurobiology, University of Lübeck, CBBM
L. Griewahn: Institute of Neurobiology, University of Lübeck, CBBM
J. Mauer: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
M. E. Hess: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
A. Moser: Department of Neurology, University of Lübeck, CBBM
S. M. Schmid: Institute of Endocrinology and Diabetes, University of Lübeck, CBBM
J. C. Brüning: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
H. Oster: Institute of Neurobiology, University of Lübeck, CBBM

DOI: https://doi.org/10.1038/s41467-020-16882-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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In addition to promoting overconsumption, palatable diets dampen daily intake patterns, which further augments metabolic dysfunction. Here, the authors find that in mice, circadian clocks in dopaminergic neurons in the ventral tegmental area drive hedonic appetite rhythms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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