Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Abstract

Microglia perform important supporting roles for neurons in the brain. Here, the authors show that microglia clear neuron-derived α-synuclein through selective autophagy (synucleinphagy) to prevent accumulation of misfolded α-synuclein and subsequent neurodegeneration in a mouse model of disease.