A time transect of exomes from a Native American population before and after European contact

John Lindo; Emilia Huerta-Sánchez; Shigeki Nakagome; Morten Rasmussen; Barbara Petzelt; Joycelynn Mitchell; Jerome S. Cybulski; Eske Willerslev; Michael DeGiorgio; Ripan S. Malhi

doi:10.1038/ncomms13175

Nature Communications (Nov 2016)

A time transect of exomes from a Native American population before and after European contact

John Lindo,
Emilia Huerta-Sánchez,
Shigeki Nakagome,
Morten Rasmussen,
Barbara Petzelt,
Joycelynn Mitchell,
Jerome S. Cybulski,
Eske Willerslev,
Michael DeGiorgio,
Ripan S. Malhi

Affiliations

John Lindo: Department of Human Genetics, University of Chicago
Emilia Huerta-Sánchez: Department of Molecular Cell Biology, University of California
Shigeki Nakagome: Department of Human Genetics, University of Chicago
Morten Rasmussen: Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen
Barbara Petzelt: Metlakatla Treaty Office
Joycelynn Mitchell: Metlakatla Treaty Office
Jerome S. Cybulski: Canadian Museum of History
Eske Willerslev: Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen
Michael DeGiorgio: Departments of Biology and Statistics, Pennsylvania State University, 502 Wartik Laboratory
Ripan S. Malhi: Carl R. Woese Institute for Genomic Biology, University of Illinois

DOI: https://doi.org/10.1038/ncomms13175
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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A First Nation population declined after European contact, likely as a result of infectious disease. Here, researchers partner with indigenous communities to analyse ancient and modern Native American exomes, and find a shift in selection pressure on immune genes, correlated to European-borne epidemics.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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