DYNAMICS OF CD14+СD16+ MONOCYTE SUBPOPULATIONS IN COMPLICATION-FREE SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING CORONARY ARTERY BYPASS GRAFT SURGERY

Abstract

Abstract. Time dynamics of CD14 and СD16 antigen expression on the surface of peripheral blood monocytes and serum cytokine contents was evaluated at different terms after surgical intervention in patients undergoing on-pump coronary artery bypass graft surgery. An association has been shown between severity of organ dysfunctions, as assessed by SOFA scores, and concentrations of IL-6 and IL-10 during early postoperative terms. On day +1 after surgery, the monocyte subpopulation profile was changed, due to relative decrease in CD14hiCD16– and increase in CD14hiCD16+. Expression of CD14 on the surface of CD14hiCD16–is reduced, along with increased expression of CD16 receptor. The observed association between relative CD14hiCD16– contents, CD16 expression level on CD14hiCD16+ monocyte subpopulation, and SOFA scores suggest a significant contribution of above-mentioned subpopulations to clinical course at early terms after surgical intervention.

Keywords

• monocytes
• cd14+cd16+ subsets
• cabg surgery
• systemic inflammatory response