Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers

Abstract

The therapeutic efficacy of anticancer nanocarriers is highly dependent on their size, shape, targeting ability, and stimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy of Doxorubicin (Dox) loaded redox responsive micellar-like nanoparticles (MNPs)based on linear 2-hydroxypropyl methacrylamide (HPMA) via histopathological evaluations. The therapeutic efficacy of DOX-loaded micellar-like Nanoparticles significantly improved while the side effects reduced as confirmed by histopathological examinations. H&E and tunnel staining of tumor tissues indicated the higher population of apoptotic tumor cells in both treatment groups containing DOX. These redox responsive crosslinked HPMA-based micellar-like nanoparticles with acceptable therapeutic efficacy and apoptosis induction in cancerous cells proved to be promising nanomedicine for breast cancer chemotherapy.

Keywords

• redox-responsive micellar nanoparticles
• histopathology
• apoptosis
• triple negative breast cancer