Bleeding Milky Way!

Abstract

Many people regard herbal plants as a safe natural product and routinely consume them for maintenance of healthy life or as home remedies without considering their potential health-threatening side effects. Here, we presented manifestations of milk thistle toxicity. The milk thistle’s flavonolignans, especially the silybin ingredient disturb the hemostatic process by dual anticoagulant and anti-platelet properties. This plant can inhibit serine proteases, including factors II and X as in the coagulation cascade as well as platelet activation by blocking adenosine diphosphate receptor and cyclooxygenase; hence, it causes bleeding diathesis.

Keywords

• Milk thistle
• Bleeding
• Platelet aggregation inhibitors
• Factor Xa inhibitors
• Antithrombins