Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys

Marco K. Wittmann; Elsa Fouragnan; Davide Folloni; Miriam C. Klein-Flügge; Bolton K. H. Chau; Mehdi Khamassi; Matthew F. S. Rushworth

doi:10.1038/s41467-020-17343-w

Nature Communications (Jul 2020)

Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys

Marco K. Wittmann,
Elsa Fouragnan,
Davide Folloni,
Miriam C. Klein-Flügge,
Bolton K. H. Chau,
Mehdi Khamassi,
Matthew F. S. Rushworth

Affiliations

Marco K. Wittmann: Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford
Elsa Fouragnan: Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford
Davide Folloni: Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford
Miriam C. Klein-Flügge: Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford
Bolton K. H. Chau: Department of Rehabilitation Sciences, The Hong Kong Polytechnic University
Mehdi Khamassi: Sorbonne Université, CNRS, Institute of Intelligent Systems and Robotics
Matthew F. S. Rushworth: Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford

DOI: https://doi.org/10.1038/s41467-020-17343-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Wittmann and colleagues show that not only single outcome events but also the global reward state (GRS) impact learning in macaques; low GRS drives explorative choices. Analyses of macaque BOLD signal reveals that GRS impacts activity in the anterior insula as well as the dorsal raphe nucleus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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