Nature Communications (Jan 2020)

A mosquito salivary protein promotes flavivirus transmission by activation of autophagy

  • Peng Sun,
  • Kaixiao Nie,
  • Yibin Zhu,
  • Yang Liu,
  • Pa Wu,
  • Ziwen Liu,
  • Senyan Du,
  • Huahao Fan,
  • Chun-Hong Chen,
  • Renli Zhang,
  • Penghua Wang,
  • Gong Cheng

DOI
https://doi.org/10.1038/s41467-019-14115-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Mosquito saliva affects transmission of flaviviruses, but underlying mechanisms are incompletely understood. Here, the authors show that Aedes aegypti venom allergen-1 (AaVA-1) promotes dengue and Zika virus transmission by activating autophagy in host immune cells of the monocyte lineage.