Influence of the PPARy2 gene polymorphism on some metabolic indices in patients with essential arterial hypertension accompanied by ischemic heart disease and type 2 diabetes mellitus

Abstract

Introduction. Currently, numerous investigations have been conducted to study the role of various genes in the development of arterial hypertension, but still they do not contain data concerning patients with comorbid pathology. Objectives. To investigate the effect of Pro12Ala polymorphism of the PPAR2 gene on metabolism rates in patients with essential arterial hypertension accompanied by stable ischemic heart disease and type 2 diabetes mellitus. Methods. Indices of carbohydrate, lipid metabolism and oxidative-antioxidant protective activity in blood were studied in 50 patients with essential arterial hypertension accompanied by stable coronary heart disease (group I) and in 62 patients with essential hypertension accompanied by stable coronary heart disease and type 2 diabetes (group II). Results. In the Ist group of patients Pro/Pro genotype (82%) predominated, and in the II-nd group of patients Pro/Pro genotype was found in 85.5%, Pro/ Ala – in 14.5% of the patients. Significant impairments (p<0.05) of carbohydrate, lipid metabolism and indices of oxidant-antioxidant homeostasis, with the exception of glutathione peroxidase and catalase in patients with Pro/Pro genotype, were detected in patients with essential hypertension accompanied by stable ischemic heart disease and type 2 diabetes with Pro/Pro and Pro/Ala genotypes of PPAR2 gene compared to the controls. Conclusions. The most pronounced disorders of carbohydrate, lipid metabolism and oxidant-antioxidant homeostasis indices are observed in patients with essential hypertension accompanied by stable ischemic heart disease and type 2 diabetes with the Pro/Pro genotype compared with the control and Pro/Ala genotype.

Keywords

• essential arterial hypertension
• ischemic heart disease
• type 2 diabetes mellitus
• metabolism
• PPAR2 gene polymorphism