Nature Communications (Mar 2021)

Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation

  • Sean Miletic,
  • Dirk Fahrenkamp,
  • Nikolaus Goessweiner-Mohr,
  • Jiri Wald,
  • Maurice Pantel,
  • Oliver Vesper,
  • Vadim Kotov,
  • Thomas C. Marlovits

DOI
https://doi.org/10.1038/s41467-021-21143-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Virulent type III secretion systems (T3SSs) or injectisomes enable pathogenic bacteria to inject effector proteins directly into the host cell cytoplasm. Structures of a needle complex engaged with the effector protein reveal the complete secretion channel and provide insights into the mechanism of substrate translocation through T3SSs.