Anti Hbs Antibody Sero-Prevalence among Extended Program of Immunization Vaccinated Children Born between Year 2009-2016 in Urban Community of City Peshawar Pakistan

Abstract

Objective: To determine the sero-prevalance of antibody against Hepatitis B virus surface antigen among EPI vaccinated children born between year 2009-2016. Study Design: Descriptive cross sectional study. Place and Duration of Study: Study was carried out among urban area children born in Peshawar city between 2009-2016 from 2 August, 2020 to 30, April 2021. Materials and Methods: This was descriptive cross-sectional study carried out among children born in city Peshawar “between” 2009-2016, using non-probability convenient sampling technique. After taking the written consent from the parents a predesigned questionnaire was filled. About 3 to 5 ml of blood was collected for anti HBs Ag test through using ELISA technique. Results were collected and analysed using SPSS version 21. Results: This study included 184 EPI HBV vaccinated children vaccinated “between” 2012 to 2016. Out of 184 children 118 (64.1%) were female belonging to the middle socio-economic class 170 (92.4%). The mean age of the study participants was 7.834 years ±2.045. Anti Hbs antibody titre revealed that out of 184 study participants 75.5% were vaccinated within last 10 years. It was observed that only 33 (17.9%) children out of 184 were immune against HBV (Antibody level > 100 mIU/ml). The study showed that there was no significant difference (p>0.05) in the immune status of the children with respect to the demography like age of child p=0.529, gender p= 0.461, place of vaccination p=0.918, economic status p=0.190. Conclusion: The EPI HBV vaccinated children lost protective anti Hbs antibody level after five years of vaccination.

Keywords

• vaccination, anti hbs antibody, sero-prevalence, hbv vaccine, immune response, immunization, children, epi.