Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil

Petya Marinova; Mariyan Hristov; Slava Tsoneva; Nikola Burdzhiev; Denica Blazheva; Aleksandar Slavchev; Evelina Varbanova; Plamen Penchev

doi:10.3390/app132413150

Applied Sciences (Dec 2023)

Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil

Petya Marinova,
Mariyan Hristov,
Slava Tsoneva,
Nikola Burdzhiev,
Denica Blazheva,
Aleksandar Slavchev,
Evelina Varbanova,
Plamen Penchev

Affiliations

Petya Marinova: Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, “Tzar Assen” Str. 24, 4000 Plovdiv, Bulgaria
Mariyan Hristov: Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, “Tzar Assen” Str. 24, 4000 Plovdiv, Bulgaria
Slava Tsoneva: Department of Analytical Chemistry and Computer Chemistry, Faculty of Chemistry, University of Plovdiv, “Tzar Asen” Str. 24, 4000 Plovdiv, Bulgaria
Nikola Burdzhiev: Department of Organic Chemistry and Pharmacognosy, Faculty of Chemistry and Pharmacy, University of Sofia, 1, J. Bourchier Av., 1164 Sofia, Bulgaria
Denica Blazheva: Department of Microbiology, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, Bulgaria
Aleksandar Slavchev: Department of Microbiology, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, Bulgaria
Evelina Varbanova: Department of Analytical Chemistry and Computer Chemistry, Faculty of Chemistry, University of Plovdiv, “Tzar Asen” Str. 24, 4000 Plovdiv, Bulgaria
Plamen Penchev: Department of Analytical Chemistry and Computer Chemistry, Faculty of Chemistry, University of Plovdiv, “Tzar Asen” Str. 24, 4000 Plovdiv, Bulgaria

DOI: https://doi.org/10.3390/app132413150
Journal volume & issue: Vol. 13, no. 24
p. 13150

Abstract

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The aim of the present study is to synthesize new metal complexes of 6-methyl-2-thiouracil and 6-propyl-2-thiouracil, elucidate their structures, and investigate their biological properties. All metal complexes were obtained after mixing water solutions of the corresponding metal salts and the ligand dissolved in DMSO and water solutions of NaOH in a metal-to-ligand ratio of 1:4:2. The structures of the new compounds are discussed based on melting point analysis (MP-AES) for Cu and Pd, UV-Vis, IR, ATR, 1H NMR, 13C NMR, and Raman spectroscopy. The interpretation of complex spectra is assisted by the data for 6-methyl-2-thiouracil and 6-propyl-2-thiouracil obtained from 1H-1H COSY, DEPT-135, HMBC and HMQC spectra. In addition, the antimicrobial activity of these complexes and the free ligands are assessed against both Gram-positive and Gram-negative bacteria, as well as yeasts. In general, the addition of metal ions improved the antimicrobial activity of both 6-methyl-2-thiouracil and 6-propyl-2-thiouracil. The Cu(II) complex with 6-methyl-2-thiouracil and the Pd(II) complex with 6-propyl-2-thiouracil exhibited the highest activity against the test microorganisms.

Published in Applied Sciences

ISSN: 2076-3417 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Engineering (General). Civil engineering (General); Science: Biology (General); Science: Physics; Science: Chemistry
Website: http://www.mdpi.com/journal/applsci

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