A case report of a drug‐induced liver injury (DILI) caused by multiple antidepressants with causality established by the updated Roussel Uclaf causality assessment method (RUCAM) and in vitro testing

Abstract

Abstract A 56‐year‐old female patient was hospitalized because of a lack of response and poor tolerance to multiple antidepressants, which included an episode of DILI. During hospitalization, the patient suffered another episode of DILI. Causality was assessed both by RUCAM and Lymphocyte Transformation Test, allowing to identify a safer medication.

Keywords

• antidepressants
• causality assessment
• drug‐induced liver injury (DILI)
• lymphocyte transformation test (LTT)
• pharmacovigilance
• Roussel Uclaf Causality Assessment Method (RUCAM)