Nature Communications (Nov 2022)
A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma
- Chao Zhang,
- Hongru Shen,
- Tielong Yang,
- Ting Li,
- Xinyue Liu,
- Jin Wang,
- Zhichao Liao,
- Junqiang Wei,
- Jia Lu,
- Haotian Liu,
- Lijie Xiang,
- Yichen Yang,
- Meng Yang,
- Duan Wang,
- Yang Li,
- Ruwei Xing,
- Sheng Teng,
- Jun Zhao,
- Yun Yang,
- Gang Zhao,
- Kexin Chen,
- Xiangchun Li,
- Jilong Yang
Affiliations
- Chao Zhang
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Hongru Shen
- Tianjin Cancer Institute, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Tielong Yang
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Ting Li
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Xinyue Liu
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Jin Wang
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Zhichao Liao
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Junqiang Wei
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Jia Lu
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Haotian Liu
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Lijie Xiang
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Yichen Yang
- Tianjin Cancer Institute, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Meng Yang
- Tianjin Cancer Institute, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Duan Wang
- Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University
- Yang Li
- Tianjin Cancer Institute, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Ruwei Xing
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Sheng Teng
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Jun Zhao
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Yun Yang
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Gang Zhao
- Department of Pathology, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Kexin Chen
- Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Xiangchun Li
- Tianjin Cancer Institute, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- Jilong Yang
- Department of Bone and Soft Tissue Tumors, Tianjin’s Clinical Research Center for Cancer, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Key Laboratory of Cancer Immunology and Biotherapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University
- DOI
- https://doi.org/10.1038/s41467-022-34877-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Studying the cell composition of acral melanoma at the single-cell level could provide some clues about its poor response to immunotherapy. Here, the authors analyse acral and cutaneous melanoma patient samples using single-cell RNA-sequencing, and reveal a severe immunosuppressive state in acral melanomas
