Journal of Clinical Medicine (Oct 2021)
Association between Severity of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of Other Spinal Ligaments in Patients with Ossification of the Posterior Longitudinal Ligament
- Soraya Nishimura,
- Takashi Hirai,
- Narihito Nagoshi,
- Toshitaka Yoshii,
- Jun Hashimoto,
- Kanji Mori,
- Satoshi Maki,
- Keiichi Katsumi,
- Kazuhiro Takeuchi,
- Shuta Ushio,
- Takeo Furuya,
- Kei Watanabe,
- Norihiro Nishida,
- Takashi Kaito,
- Satoshi Kato,
- Katsuya Nagashima,
- Masao Koda,
- Hiroaki Nakashima,
- Shiro Imagama,
- Kazuma Murata,
- Yuji Matsuoka,
- Kanichiro Wada,
- Atsushi Kimura,
- Tetsuro Ohba,
- Hiroyuki Katoh,
- Masahiko Watanabe,
- Yukihiro Matsuyama,
- Hiroshi Ozawa,
- Hirotaka Haro,
- Katsushi Takeshita,
- Yu Matsukura,
- Hiroyuki Inose,
- Masashi Yamazaki,
- Kota Watanabe,
- Morio Matsumoto,
- Masaya Nakamura,
- Atsushi Okawa,
- Yoshiharu Kawaguchi
Affiliations
- Soraya Nishimura
- Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
- Takashi Hirai
- Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
- Narihito Nagoshi
- Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
- Toshitaka Yoshii
- Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
- Jun Hashimoto
- Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
- Kanji Mori
- Department of Orthopaedic Surgery, Shiga University of Medical Science, Ōtsu 520-2192, Japan
- Satoshi Maki
- Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Chiba-shi 260-0856, Japan
- Keiichi Katsumi
- Department of Orthopedic Surgery, Niigata University Medical and Dental General Hospital, Niigata-shi 951-8520, Japan
- Kazuhiro Takeuchi
- Department of Orthopedic Surgery, National Hospital Organization Okayama Medical Center, Okayama-shi 701-1192, Japan
- Shuta Ushio
- Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
- Takeo Furuya
- Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Chiba-shi 260-0856, Japan
- Kei Watanabe
- Department of Orthopedic Surgery, Niigata University Medical and Dental General Hospital, Niigata-shi 951-8520, Japan
- Norihiro Nishida
- Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan
- Takashi Kaito
- Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita 565-0871, Japan
- Satoshi Kato
- Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa 920-8641, Japan
- Katsuya Nagashima
- Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8577, Japan
- Masao Koda
- Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8577, Japan
- Hiroaki Nakashima
- Department of Orthopaedics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Shouwa-ku, Nagoya 464-8601, Japan
- Shiro Imagama
- Department of Orthopaedics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Shouwa-ku, Nagoya 464-8601, Japan
- Kazuma Murata
- Department of Orthopedic Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan
- Yuji Matsuoka
- Department of Orthopedic Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan
- Kanichiro Wada
- Department of Orthopedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan
- Atsushi Kimura
- Department of Orthopedics, Jichi Medical University, Shimotsuke 329-0498, Japan
- Tetsuro Ohba
- Department of Orthopedic Surgery, University of Yamanashi, Chuo 409-3898, Japan
- Hiroyuki Katoh
- Department of Orthopedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara 259-1193, Japan
- Masahiko Watanabe
- Department of Orthopedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara 259-1193, Japan
- Yukihiro Matsuyama
- Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu 431-3125, Japan
- Hiroshi Ozawa
- Department of Orthopaedic Surgery, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan
- Hirotaka Haro
- Department of Orthopedic Surgery, University of Yamanashi, Chuo 409-3898, Japan
- Katsushi Takeshita
- Department of Orthopedics, Jichi Medical University, Shimotsuke 329-0498, Japan
- Yu Matsukura
- Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
- Hiroyuki Inose
- Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
- Masashi Yamazaki
- Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8577, Japan
- Kota Watanabe
- Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
- Morio Matsumoto
- Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
- Masaya Nakamura
- Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
- Atsushi Okawa
- Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
- Yoshiharu Kawaguchi
- Department of Orthopedic Surgery, Faculty of Medicine, University of Toyama, Toyama-shi 930-0194, Japan
- DOI
- https://doi.org/10.3390/jcm10204690
- Journal volume & issue
-
Vol. 10,
no. 20
p. 4690
Abstract
Background: Although diffuse idiopathic skeletal hyperostosis (DISH) is known to coexist with the ossification of spinal ligaments (OSLs), details of the radiographic relationship remain unclear. Methods: We prospectively collected data of 239 patients with symptomatic cervical ossification of the posterior longitudinal ligament (OPLL) and analyzed the DISH severity on whole-spine computed tomography images, using the following grades: grade 0, no DISH; grade 1, DISH at T3–T10; grade 2, DISH at both T3–T10 and C6–T2 and/or T11–L2; and grade 3, DISH beyond C5 and/or L3. Ossification indices were calculated as the sum of vertebral and intervertebral levels with OSL for each patient. Results: DISH was found in 107 patients (44.8%), 65 (60.7%) of whom had grade 2 DISH. We found significant associations of DISH grade with the indices for cervical OPLL (r = 0.45, p p p p p p < 0.0001). Conclusion: The DISH grade correlated with the indices of OSL at each high-prevalence level as well as the whole spine.
Keywords
- cervical ossification of the posterior longitudinal ligament
- diffuse idiopathic skeletal hyperostosis
- whole-spine computed tomography
- grading system
- multicenter study
