New secoiridoid Glycosides from the Roots of Picrorhiza Scrophulariiflora

Abstract

Three new secoiridoid glycosides, named picrogentiosides A (1), B (2) and C (3), have been isolated from the underground parts of Picrorhiza Scrophulariiflora, together with the two known compounds plantamajoside (4) and plantainoside D (5). Their structures were established by spectroscopic analyses and comparisons with data from related compounds. A pilot pharmacological study showed that picrogentiosides A (1) and B (2) have an immunomodulatory effect in vitro.

Keywords

• Picrorhiza scrophulariiflora
• Secoiridoid glycosides
• Picrogentiosides A
• B and C
• Immunoenhancement