Nature Communications (Feb 2018)
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding
- Hou-Fu Guo,
- Chi-Lin Tsai,
- Masahiko Terajima,
- Xiaochao Tan,
- Priyam Banerjee,
- Mitchell D. Miller,
- Xin Liu,
- Jiang Yu,
- Jovita Byemerwa,
- Sarah Alvarado,
- Tamer S. Kaoud,
- Kevin N. Dalby,
- Neus Bota-Rabassedas,
- Yulong Chen,
- Mitsuo Yamauchi,
- John A. Tainer,
- George N. Phillips,
- Jonathan M. Kurie
Affiliations
- Hou-Fu Guo
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Chi-Lin Tsai
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Masahiko Terajima
- North Carolina Oral Health Institute, School of Dentistry, University of North Carolina at Chapel Hill
- Xiaochao Tan
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Priyam Banerjee
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Mitchell D. Miller
- Department of Biosciences, Rice University
- Xin Liu
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jiang Yu
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jovita Byemerwa
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Sarah Alvarado
- Department of Biosciences, Rice University
- Tamer S. Kaoud
- Division of Medicinal Chemistry, Targeted Therapeutic Drug Discovery and Development Program, College of Pharmacy, The University of Texas at Austin
- Kevin N. Dalby
- Division of Medicinal Chemistry, Targeted Therapeutic Drug Discovery and Development Program, College of Pharmacy, The University of Texas at Austin
- Neus Bota-Rabassedas
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Yulong Chen
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Mitsuo Yamauchi
- North Carolina Oral Health Institute, School of Dentistry, University of North Carolina at Chapel Hill
- John A. Tainer
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- George N. Phillips
- Department of Biosciences, Rice University
- Jonathan M. Kurie
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-02859-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis.
