Nature Communications (Jun 2022)
Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms
- Caroline G. Atyeo,
- Lydia L. Shook,
- Sara Brigida,
- Rose M. De Guzman,
- Stepan Demidkin,
- Cordelia Muir,
- Babatunde Akinwunmi,
- Arantxa Medina Baez,
- Maegan L. Sheehan,
- Erin McSweeney,
- Madeleine D. Burns,
- Ruhi Nayak,
- Maya K. Kumar,
- Chinmay D. Patel,
- Allison Fialkowski,
- Dana Cvrk,
- Ilona T. Goldfarb,
- Lael M. Yonker,
- Alessio Fasano,
- Alejandro B. Balazs,
- Michal A. Elovitz,
- Kathryn J. Gray,
- Galit Alter,
- Andrea G. Edlow
Affiliations
- Caroline G. Atyeo
- Ragon Institute of MGH, MIT, and Harvard
- Lydia L. Shook
- Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
- Sara Brigida
- Vincent Center for Reproductive Biology, Massachusetts General Hospital
- Rose M. De Guzman
- Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
- Stepan Demidkin
- Vincent Center for Reproductive Biology, Massachusetts General Hospital
- Cordelia Muir
- Vincent Center for Reproductive Biology, Massachusetts General Hospital
- Babatunde Akinwunmi
- Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School
- Arantxa Medina Baez
- Vincent Center for Reproductive Biology, Massachusetts General Hospital
- Maegan L. Sheehan
- Ragon Institute of MGH, MIT, and Harvard
- Erin McSweeney
- Vincent Center for Reproductive Biology, Massachusetts General Hospital
- Madeleine D. Burns
- Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
- Ruhi Nayak
- Vincent Center for Reproductive Biology, Massachusetts General Hospital
- Maya K. Kumar
- Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School
- Chinmay D. Patel
- Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School
- Allison Fialkowski
- Vincent Center for Reproductive Biology, Massachusetts General Hospital
- Dana Cvrk
- Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
- Ilona T. Goldfarb
- Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
- Lael M. Yonker
- Mucosal Immunology and Biology Research Center, Massachusetts General Hospital
- Alessio Fasano
- Mucosal Immunology and Biology Research Center, Massachusetts General Hospital
- Alejandro B. Balazs
- Ragon Institute of MGH, MIT, and Harvard
- Michal A. Elovitz
- Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania
- Kathryn J. Gray
- Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School
- Galit Alter
- Ragon Institute of MGH, MIT, and Harvard
- Andrea G. Edlow
- Department of Obstetrics & Gynecology, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-31169-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Pregnant individuals infected with SARS-CoV-2 are at high risk of morbidity and mortality, in addition to adverse pregnancy outcomes, yet little is known regarding trimester-specific immunity and maternal protection from COVID-19 vaccine platforms. Authors utilise a systems serology approach to characterise the material antibody response and the transplacental antibody transfer, dependent on vaccine platform and trimester of vaccination.
