Research Progress on the Correlation of Dyslipidemia with Colorectal Serrated Lesions and Colorectal Cancer

Abstract

Dyslipidemia may be related to the occurrence and development of colorectal tumors. Numerous studies have confirmed that dyslipidemia increases the risk of colorectal adenomas at present; however, the association of dyslipidemia with colorectal serrated lesions and colorectal cancer is still controversial, and there are few relevant reviews in China. This article comprehensively explores the correlation of dyslipidemia with colorectal serrated lesions and colorectal cancer, analyzes the possible causes of controversy, identifies the directions of subsequent researches, and discusses the role of dyslipidemia in the occurrence and progression of colorectal tumors. This article indicates that dyslipidemia is associated with colorectal serrated lesions and colorectal cancer. Dyslipidemia may be involved in the development of colorectal tumors through the interaction of multiple mechanisms such as insulin resistance, inflammatory factors, oxidative stress, high-fat diet and immunosuppression. The incidence of colorectal cancer is increasing yearly with a relatively slower natural course and more definite precancerous lesions. Therefore, the clarification of correlation between lipid indexes and colorectal tumors can facilitate early prevention and targeted screening of colorectal tumors and provide a reference for formulating targeted prevention strategies for colorectal cancer.

Keywords

• hyperlipidemias|dyslipidemias|colorectal neoplasms|colorectal serrated lesions|colorectal cancer|review