Five new limonoids isolated from Walsura robusta

Li Hou; Cui-Xuan Mei; Chun-Mao Yuan; Gui-Hua Tang; Duo-Zhi Chen; Qing Zhao; Hong-Ping He; Ming-Ming Cao; Xiao-Jiang Hao

doi:10.1007/s13659-023-00371-6

Natural Products and Bioprospecting (Feb 2023)

Five new limonoids isolated from Walsura robusta

Li Hou,
Cui-Xuan Mei,
Chun-Mao Yuan,
Gui-Hua Tang,
Duo-Zhi Chen,
Qing Zhao,
Hong-Ping He,
Ming-Ming Cao,
Xiao-Jiang Hao

Affiliations

Li Hou: State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences
Cui-Xuan Mei: State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences
Chun-Mao Yuan: State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences
Gui-Hua Tang: State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences
Duo-Zhi Chen: State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences
Qing Zhao: School of Ethnic Medicine, and School of Chinese Materia Medical, Yunnan University of Chinese Medicine
Hong-Ping He: State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences
Ming-Ming Cao: State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences
Xiao-Jiang Hao: State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences

DOI: https://doi.org/10.1007/s13659-023-00371-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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Abstract Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1–4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1–6 exhibited good cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.

Published in Natural Products and Bioprospecting

ISSN: 2192-2195 (Print); 2192-2209 (Online)
Publisher: SpringerOpen
Country of publisher: Germany
LCC subjects: Science: Botany
Website: http://www.springer.com/13659

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