Antihyperglycemic and histological effects on the pancreas of the aqueous leaves extract of Annona squamosa L. in normal and diabetic rats

Abstract

The purposes of our present study were to investigate the antihyperglycemic effect of aqueous leaves extract ofAnnona squamosa L. at different doses and histology of the pancreas in normal and diabetic rats after receiving the extract. The study of antihyperglycemic activities was undertaken by oral administration of vehicle, glibenclamide (3 mg/kg) and water leaves extract of Annona squamosa L (125, 250 and 500 mg/kg) for 12 days. Fasting blood glucose levels were recorded on the fifth and twelfth days of administration and the third day after stopping administration. The results showed that diabetic rats receiving the doses of 250 and 500 mg/kg leaves extract had statistically significant (pAnnona squamosa L. has an antihyperglycemic effect and is able toimprove the histological appearance of diabetic rat pancreas.

Keywords

• antihyprglycemic effect
• Annona squamosa L.
• histology
• pancreas