A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer’s Disease

Gustavo Provensi; Fabrizio Carta; Alessio Nocentini; Claudiu  T. Supuran; Fiorella Casamenti; M.  Beatrice Passani; Silvia Fossati

doi:10.3390/ijms20194724

International Journal of Molecular Sciences (Sep 2019)

A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer’s Disease

Gustavo Provensi,
Fabrizio Carta,
Alessio Nocentini,
Claudiu T. Supuran,
Fiorella Casamenti,
M. Beatrice Passani,
Silvia Fossati

Affiliations

Gustavo Provensi: Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology of Toxicology, University of Florence, 50139 Florence, Italy
Fabrizio Carta: Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019 Florence, Italy
Alessio Nocentini: Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019 Florence, Italy
Claudiu T. Supuran: Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019 Florence, Italy
Fiorella Casamenti: Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology of Toxicology, University of Florence, 50139 Florence, Italy
M. Beatrice Passani: Department of Health Sciences (DSS), Section of Clinical Pharmacology and Oncology, University of Florence, 50139 Florence, Italy
Silvia Fossati: Alzheimer′s Center at Temple (ACT), Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA

DOI: https://doi.org/10.3390/ijms20194724
Journal volume & issue: Vol. 20, no. 19
p. 4724

Abstract

Read online

The increase in the incidence of neurodegenerative diseases, in particular Alzheimer’s Disease (AD), is a consequence of the world′s population aging but unfortunately, existing treatments are only effective at delaying some of the symptoms and for a limited time. Despite huge efforts by both academic researchers and pharmaceutical companies, no disease-modifying drugs have been brought to the market in the last decades. Recently, several studies shed light on Carbonic Anhydrases (CAs, EC 4.2.1.1) as possible new targets for AD treatment. In the present review we summarized preclinical and clinical findings regarding the role of CAs and their inhibitors/activators on cognition, aging and neurodegeneration and we discuss future challenges and opportunities in the field.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

About the journal

Abstract

Keywords