Nature Communications (Sep 2021)
New-onset IgG autoantibodies in hospitalized patients with COVID-19
- Sarah Esther Chang,
- Allan Feng,
- Wenzhao Meng,
- Sokratis A. Apostolidis,
- Elisabeth Mack,
- Maja Artandi,
- Linda Barman,
- Kate Bennett,
- Saborni Chakraborty,
- Iris Chang,
- Peggie Cheung,
- Sharon Chinthrajah,
- Shaurya Dhingra,
- Evan Do,
- Amanda Finck,
- Andrew Gaano,
- Reinhard Geßner,
- Heather M. Giannini,
- Joyce Gonzalez,
- Sarah Greib,
- Margrit Gündisch,
- Alex Ren Hsu,
- Alex Kuo,
- Monali Manohar,
- Rong Mao,
- Indira Neeli,
- Andreas Neubauer,
- Oluwatosin Oniyide,
- Abigail E. Powell,
- Rajan Puri,
- Harald Renz,
- Jeffrey Schapiro,
- Payton A. Weidenbacher,
- Richard Wittman,
- Neera Ahuja,
- Ho-Ryun Chung,
- Prasanna Jagannathan,
- Judith A. James,
- Peter S. Kim,
- Nuala J. Meyer,
- Kari C. Nadeau,
- Marko Radic,
- William H. Robinson,
- Upinder Singh,
- Taia T. Wang,
- E. John Wherry,
- Chrysanthi Skevaki,
- Eline T. Luning Prak,
- Paul J. Utz
Affiliations
- Sarah Esther Chang
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine
- Allan Feng
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine
- Wenzhao Meng
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Sokratis A. Apostolidis
- Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania
- Elisabeth Mack
- Department of Hematology, Oncology, Immunology, Philipps University Marburg
- Maja Artandi
- Department of Medicine, Division of Primary Care and Population Health, Stanford University School of Medicine
- Linda Barman
- Department of Medicine, Division of Primary Care and Population Health, Stanford University School of Medicine
- Kate Bennett
- Molecular Pathology and Imaging Core, Department of Medicine, Gastroenterology Division, Perelman School of Medicine, University of Pennsylvania
- Saborni Chakraborty
- Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine
- Iris Chang
- Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine
- Peggie Cheung
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine
- Sharon Chinthrajah
- Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine
- Shaurya Dhingra
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine
- Evan Do
- Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine
- Amanda Finck
- Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
- Andrew Gaano
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Reinhard Geßner
- Institute of Laboratory Medicine, Philipps University Marburg
- Heather M. Giannini
- Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center
- Joyce Gonzalez
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Sarah Greib
- Institute of Laboratory Medicine, Philipps University Marburg
- Margrit Gündisch
- Institute of Laboratory Medicine, Philipps University Marburg
- Alex Ren Hsu
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine
- Alex Kuo
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine
- Monali Manohar
- Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine
- Rong Mao
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine
- Indira Neeli
- Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center
- Andreas Neubauer
- Department of Hematology, Oncology, Immunology, Philipps University Marburg
- Oluwatosin Oniyide
- Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania
- Abigail E. Powell
- Department of Biochemistry, Stanford University School of Medicine
- Rajan Puri
- Department of Medicine, Division of Primary Care and Population Health, Stanford University School of Medicine
- Harald Renz
- Institute of Laboratory Medicine, Philipps University Marburg
- Jeffrey Schapiro
- TPMG Regional Reference Laboratory, Kaiser Permanente Northern California
- Payton A. Weidenbacher
- Department of Biochemistry, Stanford University School of Medicine
- Richard Wittman
- Department of Medicine, Division of Primary Care and Population Health, Stanford University School of Medicine
- Neera Ahuja
- Department of Medicine, Division of Hospital Medicine, Stanford University School of Medicine
- Ho-Ryun Chung
- Institute for Medical Bioinformatics and Biostatistics, Philipps University Marburg
- Prasanna Jagannathan
- Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine
- Judith A. James
- Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation
- Peter S. Kim
- Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center
- Nuala J. Meyer
- Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
- Kari C. Nadeau
- Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine
- Marko Radic
- Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center
- William H. Robinson
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine
- Upinder Singh
- Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine
- Taia T. Wang
- Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine
- E. John Wherry
- Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
- Chrysanthi Skevaki
- Institute of Laboratory Medicine, Philipps University Marburg
- Eline T. Luning Prak
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Paul J. Utz
- Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25509-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Infection with SARS-CoV2 and the development of Coronavirus disease 2019 (COVID-19) has been linked to induction of autoimmunity and autoantibody production. Here the authors characterise the new-onset IgG autoantibody response in hospitalised patients with COVID-19 which they correlate to the magnitude of the SARS-CoV2 response.
